Sound the Alarmin: Interleukin-33 Commandeers the Gastric Immune Response
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منابع مشابه
Sound the Alarmin: Interleukin-33 Commandeers the Gastric Immune Response
nterleukin-33 (IL-33) is a member of the IL-1 superIfamily and activates group 2 innate lymphoid cells (ILC2), mast cells, and their progenitors. Studies indicate that ILCs, which secrete copious amounts of IL-5 and IL-13 in response to IL-33, play critical roles in directing the development of type-2 immunity and allergic inflammation. In this issue of Cellular and Molecular Gastroenterology a...
متن کاملThe Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury
Inflammation is a prominent feature of CNS injury that heavily influences neuronal survival, yet the signals that initiate and control it remain poorly understood. Here we identify the nuclear alarmin, interleukin (IL)-33, as an important regulator of the innate immune response after CNS injury. IL-33 is expressed widely throughout the healthy brain and is concentrated in white mater due to pre...
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Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins-including the defensins, LL-37, and HMGB1-in tumor dev...
متن کاملInflammation-induced expression of the alarmin interleukin 33 can be suppressed by galacto-oligosaccharides.
BACKGROUND The alarmin interleukin 33 (IL-33) and its receptor ST2 play an important role in mucosal barrier tissues, and seem to be crucial for Th2-cell mediated host defense. Galacto-oligosaccharides (GOS), used in infant formulas, exhibit gut and immune modulatory effects. To enhance our understanding of the immunomodulatory capacity of GOS, this study investigated the impact of dietary GOS ...
متن کاملThe alarmin interleukin-33 drives protective antiviral CD8⁺ T cell responses.
Pathogen-associated molecular patterns decisively influence antiviral immune responses, whereas the contribution of endogenous signals of tissue damage, also known as damage-associated molecular patterns or alarmins, remains ill defined. We show that interleukin-33 (IL-33), an alarmin released from necrotic cells, is necessary for potent CD8(+) T cell (CTL) responses to replicating, prototypic ...
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ژورنال
عنوان ژورنال: Cellular and Molecular Gastroenterology and Hepatology
سال: 2015
ISSN: 2352-345X
DOI: 10.1016/j.jcmgh.2015.01.008